Jose Mourinho returned to Stamford Bridge for the first time as an opponent manager but his homecoming turned into utter humiliation as the Manchester United players surrendered haplessly.
Pedro started the proceedings as early as in 30 seconds when took advantage of sloppy defending and netted the opening goal.
Shaking up from his poor form, Gary Cahill scored the second goal which helped Chelsea to take a convincing 2-0 lead in the first half.
Eden Hazard and N'Golo Kante scored the other two goals in the second half to decimate the Red Devils completely.
In other matches of the week, Liverpool once again registered a comfortable 2-1 win over West Brom. Manchester City's woes continued as they were yet again held to a 1-1 draw by Southampton.
Arsenal's good run of form took a halt as they too were restricted by minnows Middlesbrough for a 0-0 draw.
Reigning champions Leicester City returned to winning ways with a 3-1 win over Crystal Palace.
AFC Bournemouth 0-0 Tottenham Hotspur
Arsenal 0-0 Middlesbrough
Leicester City 3-1 Crystal Palace
West Ham United 1-0 Sunderland
Hull City 0-2 Stoke City
Swansea City 0-0 Watford
Burnley 2-1 Everton
Liverpool 2-1 West Bromwich Albion
Manchester City 1-1 Southampton
Chelsea 4-0 Manchester United
Goalkeeper: Thibaut Courtois
Defenders: Winston Reid, Gary Cahill, Christian Fuchs
Midfielders: Eden Hazard, N'Golo Kante, Phillipe Coutinho, Xherdan Shaqiri
Strikers: Pedro, Ahmed Musa, Sadio Mane