Levante vs Real Madrid
Real Madrid play against Levante UD, an opponent who have caused Zinedine Zidane's side plenty of problems through recent seasons.
Los Blancos are on a 15-game unbeaten streak in La Liga however, while Los Granotas have lost five of their last six.
Real Sociedad vs Valencia
The focus will be on top four qualification when Real Sociedad take on Valencia CF.
The spotlight will at the Reale Arena will be on two of La Liga's most in-form emerging stars in La Real's Alexander Isak (pictured) and Valencia's Ferran Torres.
Getafe vs Sevilla
Third-placed Getafe CF are at home to fifth-placed Sevilla FC.
It is another clash of UEFA Champions League qualification chasers while a keen rivalry has grown between these two teams recently helped by Getafe's 3-0 win in the fixture late last term.
Atletico Madrid vs Villarreal
The last game of week 25 should also be tight and tense, with third-placed Atletico Madrid at home to sixth placed Villarreal CF.
The Yellow Submarine have been a bogey team for Diego Simeone's side in recent years, although the rojiblancos did win this fixture 2-0 last season.