The first game was tough for the Indian, as the world No.37 put up a fight, staying within a couple of points of his opponent throughout. Ghosal was able to take it 11-8, before then navigating his way through the second.
The world No.11 then took the first five points in the third game, as he showed his dominance in the match. Although Serme attempted to come back into it, it was too little too late, and the ace Indian advanced to the round-of-16 at the PSA World Championships.
In the pre-quarterfinals, Ghosal will face Egyptian world No.2 and top seed Mohamed El Shorbagy on Tuesday.
"It's the World Championships, so you're playing the best players in every single round. The depth in men's squash today is unbelievable like you're seeing through this week. Everyone has to be focussed from the first point. It's a tough sport so it is good to win 3-0," Ghosal said.
Tricky first round
Earlier in the first round, Ghosal came through a tricky test over compatriot Mahesh Mangaonkar in an all-Indian affair.
Ghosal looked in control of the match after the first two games, as he used his skill and experience to win both by the same margin, 11-7. However, the third game would be much more difficult, as Mangaonkar tried to fight back before Ghosal prevailed 18-16.