The 25-year-old from Florida had earned his right to the exuberant celebration after a performance that saw him eclipse Michael Johnson's long-standing record of 19.32sec to become the fastest American 200M runner in history.
"Today is my day and I finally got to do what I've dreamed about for years. I was hoping it was going to be a fast time because I thought it was going to be slow," an elated Lyles said.
The outcome had never been in doubt from the moment Lyles erupted smoothly from the blocks, hitting top speed within 50M to open up a comfortable lead coming off the bend.
Bednarek and Knighton tried to stay in touch, but there was no stopping Lyles, who seemed to find an extra gear to pull away and eventually take the tape ahead of Bednarek and Knighton.
Shericka denies Fraser-Pryce
Earlier, in the women's 200M race, Shericka denied Shelly-Ann Fraser-Pryce a sprint double by winning the race with a Championships Record of 21.45.
Fraser-Pryce, who had won the 100M had to settle for silver with a season's best of 21.81 while Great Britain's defending champion Dina Asher-Smith prevented a Jamaican cleansweep by clinching bronze in 22.02.
Neeraj in final
Meanwhile, Indian javelin ace Neeraj made it to the finals with a stunning throw of 88.39M. However, the 24-year-old could not top the field as he was pipped by Grenada's Anderson Peters who covered a distance of 89.91M.
The men's javelin throw final will be held on Sunday (July 24) at 7.05 am IST. Just three more days of high-octane action are left at the World Athletics Championships Oregon 2022, which is set to conclude on July 24.