Independent rider
Cal Crutchlow (LCR Honda Castrol) kept that raging just outside the top three.
The British rider took fourth and ending Day 1 fastest Independent Team rider as he vies to extend his lead this weekend in those standings.
Rear rubber
It wasn't until the final five minutes when the battle for Friday's honours started to heat up at a scorching MotorLand Aragon, with Dovizioso setting the first sub 1:48 laptime of the weekend and Crutchlow quickly following suit.
However, with fresh soft rear rubber, six-time world champion Marquez soon marked 'his' territory - with a 1:47.382 putting him 0.453 faster than the rest.
Final lap
Lorenzo, meanwhile, had dropped to outside the top ten but on his final lap of FP2, the Spaniard turned up the wick to launch himself into P2 to finish the day 0.138 behind Marquez.
Behind the top four, Team Suzuki Ecstar's Andrea Iannone put his GSX-RR into fifth as the day came to a close, with the Italian the only other rider to venture into the 1:47s as he led for the majority of FP2.
Bridge gap
Rounding out the provisional Q2 places were the two Movistar Yamaha MotoGP riders -- Valentino Rossi and Maverick Vinales.
Can the Yamahas bridge the gap to the front on Saturday and stay in that top ten at a more difficult venue than Misano?