Runaway leader
Poleman Bagnaia was not waiting around once it was lights out, with the Italian taking the holeshot ahead of team-mate Jack Miller, who had executed a brilliant opening corner move to get ahead of Quartararo into P2.
By the end of the first lap, Bagnaia had opened up an impressive 1sec lead over Miller in second, with Quartararo and Marc Marquez (Repsol Honda Team) not far behind the Aussie.
Imperious rider
As the laps ticked down, the gap between Bagnaia and Quartararo did too and there was a frisson of tension for the race leader on the horizon: by four to go, El Diablo got within eight tenths and then half a second, making it game on.
Could Quartararo go for a lunge? Not in the end, Bagnaia once again proving impervious under pressure, painting Misano red and taking his second win in a week.
Ist podium for Bastianini
Behind that duel, it was beauty from the 'Beast'. Bastianini kept his stunning pace to the end, taking a comfortable third place.
Comfortable is an understatement, however, as the rookie put together a truly stunning race on best lap record pace to take his first premier class podium, and on home turf to boot.
Advantage Quartarao
Bagnaia continues to hold the cards on track as the MotoGP caravan heads for Austin in two week's time.
But Quartararo has the ace in the standings. It's five points closer now though, and the Circuit of The Americas has proven a very different hunting ground to Misano in the past. So brace up for the horsepower rodeo!