| Player | 50s | Year | |
| MD Raj | 71 | 1999 to 2021-22 | |
| CM Edwards | 55 | 1997 to 2015 | |
| L Wolvaardt | 53 | 2015-16 to 2025-26 | |
| SW Bates | 50 | 2005-06 to 2024-25 | |
| SR Taylor | 50 | 2008 to 2025-26 | |
| SS Mandhana | 49 | 2013-14 to 2025-26 | |
| KL Rolton | 41 | 1995-96 to 2009 | |
| EA Perry | 40 | 2007-08 to 2025-26 | |
| DA Hockley | 38 | 1981-82 to 2000-01 | |
| MM Lanning | 36 | 2010-11 to 2022-23 | |
| TT Beaumont | 36 | 2016 to 2025-26 | |
| NR Sciver | 36 | 2013-14 to 2025-26 | |
| BJ Clark | 35 | 1990-91 to 2004-05 | |
| AE Satterthwaite | 34 | 2008-09 to 2021-22 | |
| SC Taylor | 31 | 1999-00 to 2011 | |
| H Kaur | 31 | 2009-10 to 2025-26 | |
| HC Knight | 30 | 2010-11 to 2025-26 | |
| AMC Jayangani | 29 | 2010-11 to 2025-26 | |
| AJ Blackwell | 28 | 2004-05 to 2017-18 | |
| SJ Taylor | 27 | 2006 to 2019 | |
| SFM Devine | 27 | 2009-10 to 2025-26 | |
| AJ Healy | 27 | 2012-13 to 2025-26 | |
| BL Mooney | 27 | 2015-16 to 2025-26 | |
| L Lee | 26 | 2013-14 to 2021 | |
| LM Keightley | 25 | 1995-96 to 2005 | |
| DJS Dottin | 25 | 2008 to 2021-22 | |
| SE Luus | 23 | 2016 to 2025-26 | |
| Sidra Ameen | 22 | 2016 to 2026 | |
| EC Drumm | 21 | 1993-94 to 2005-06 | |
| RL Haynes | 21 | 2009-10 to 2021-22 | |
| Bismah Maroof | 21 | 2010-11 to 2023-24 | |
| M Kapp | 21 | 2012-13 to 2025-26 | |
| M du Preez | 20 | 2006-07 to 2021-22 | |
| HM Tiffen | 19 | 2000-01 to 2008-09 | |
| A Chopra | 19 | 1995-96 to 2009-10 | |
| DB Sharma | 19 | 2016-17 to 2025-26 | |
| LC Sthalekar | 18 | 2002-03 to 2010-11 | |
| PG Raut | 18 | 2010-11 to 2020-21 | |
| AE Jones | 18 | 2017-18 to 2025-26 | |
| HK Matthews | 18 | 2014-15 to 2025-26 | |
| Javeria Khan | 17 | 2010-11 to 2019 | |
| Farzana Haque | 17 | 2012-13 to 2024-25 | |
| AC Kerr | 17 | 2018 to 2026 | |
| JP Sharma | 16 | 2002 to 2008 | |
| T Chetty | 16 | 2008-09 to 2017 | |
| NE Bolton | 16 | 2013-14 to 2017-18 | |
| S Nitschke | 15 | 2006-07 to 2011 | |
| GH Lewis | 15 | 2021-22 to 2025-26 | |
| CL Tryon | 15 | 2014-15 to 2025-26 | |
| RJ Rolls | 14 | 1998-99 to 2006-07 | |
| MF Fahey | 14 | 2003-04 to 2010 | |
| PES Litchfield | 14 | 2022-23 to 2025-26 | |
| ML Green | 14 | 2018 to 2026 | |
| JA Brittin | 13 | 1981-82 to 1997-98 | |
| LS Greenway | 13 | 2006-07 to 2015 | |
| A Jain | 12 | 1993 to 2004-05 | |
| C Brits | 12 | 2004-05 to 2012-13 | |
| A Brindle | 12 | 2001-02 to 2013-14 | |
| SJ McGlashan | 11 | 2004-05 to 2013-14 | |
| RH Priest | 11 | 2013-14 to 2017 | |
| Nida Dar | 11 | 2011-12 to 2022-23 | |
| T Brits | 11 | 2023-24 to 2025-26 | |
| AK Gardner | 11 | 2018-19 to 2025-26 | |
| JI Rodrigues | 11 | 2018-19 to 2025-26 | |
| D van Niekerk | 11 | 2012-13 to 2025-26 | |
| Sharmin Akter | 11 | 2011-12 to 2026 | |
| LA Reeler | 10 | 1983-84 to 1988-89 | |
| NJ Browne | 10 | 2003-04 to 2012-13 | |
| KV Jain | 10 | 2003-04 to 2012-13 | |
| Nain Abidi | 10 | 2008-09 to 2017 | |
| Aliya Riaz | 10 | 2018-19 to 2024-25 | |
| BM Halliday | 10 | 2020-21 to 2025-26 | |
| P Rawal | 10 | 2024-25 to 2025-26 | |
| Nigar Sultana | 10 | 2016-17 to 2026 |