Zinedine Zidane's Real Madrid are presently at the top of the league table and will hold an upper hand over their opponents Atletico Madrid who have had a topsy-turvy start to their campaign this season.
Real Madrid have only one injury concern in their starting XI. German midfielder Toni Kroos is virtually ruled out of the game.
Kroos had fractured his metatarsal while playing against Leganes last game week. Matteo Kovacic is likely to replace the talismanic midfielder.
Zidane will welcome back one of his most trusted lieutenant Luka Modric who comes back from injury.
The front three will remain same, the famous trio of BBC, Karim Benzema, Cristiano Ronaldo and Gareth Bale.
Atletico Madrid do not have any injury concern as such. Diego Simeone will field the best possible team in this crucial Madrid derby. A full three points will take them 24 points only 3 behind Real.
Atletico Madrid (4-4-2)
Goalkeeper: Jan Oblak
Defenders: Juanfran, Diego Godin, Jose Gimenez, Felipe Luis
Midfielders: Saul Niguez, Koke, Augusto Fernandez, Yannick Carrasco
Strikers: Antoine Griezmann, Kevin Gameiro
Real Madrid (4-3-3)
Goalkeeper: Keylor Navas
Defenders: Dani Carvajal, Pepe, Sergio Ramos, Marcelo
Midfielders: Matteo Kovacic, Luka Modric, James Rodriguez
Strikers: Cristiano Ronaldo, Karim Benzema, Gareth Bale.
Atletico Madrid 1-1 Real Madrid