A typical Clasico played out with high intensity and desire as both teams created chances in the first half. But it took 50 minutes for the first goal to arrive through Cesc fabregas, who collected Lionel Messi's through pass slotted home past Diego Alves.
Nine minutes from time, Varane, Madrid's most impressive player on the night, equalised with a header through Mesut Ozil's cross.
Jose Mourinho handed Lopez his debut in goal ahead of Adan and the injured Iker Casillas. But it was on the other end of the pitch where Jose Pinto was put to test first, pushing away Cristiano Ronaldo's dipping free kick.
Barcelona began to control the game with possession and one-touch football but Madrid were the more threatening side moving forward.
Here is look at the match stats.
* Barcelona had a total possession of 67% with 88% pass accuracy.
* Both teams had 10 shots on goal with four on target for Barcelona and two for Real Madrid. Barca hit the wood work once.
* Real Madrid were caught offside twice while Barcelona 6 times.
* Real Madrid commited 19 fouls to Barcelona's 5 fouls. Each teams were shown three yellow card.
*Barcelona completed a total of 743 passes while Real managed 372.
*Rafael Varane was awarded Man of the Match.