Fulham were recently thrashed by United 4-1 at Old Trafford but Martin Jol's men won 3-1 against West Ham in midweek. The Cottagers home form won't give them any confidence boost and the absence of Dimitar Berbatov will be a huge concern.
Fulham registered only their third win in 16 league games against the Hammers. New signings in the transfer window should provide some stability in midfield with Emmanuel Frimponf and Urby Emmanuelson.
Defence should also be a concern as they have failed to keep a clean sheet in their last 10 league games.
United somehow managed to clinch three points against Southampton, who were the better side in the second half. But Sir Alex Ferguson doesn't need to worry about his players availability.
The Red Devils current form could well and truly secure them their 20th league title. United's crucial test this month will be in the Champions League against Real Madrid.
Fulham may miss Steve Sidwell, Mahamadou Diarra, Kerim Frei and Kieran Richardson due to injury concerns but AC Milan midfielder Emmanuelson could make his debut alongwith Frimpong.
United are without Ashley Young but defender Rio Ferdinand could make a comeback along side centre-half Jonny Evans.
*Manchester United have won six of their last seven matches against Fulham.
*United have 10 of their last 12 games in the Premier League.
Fulham (4-2-3-1): Schwarzer-Riether, Senderos, Hangeland, Riise-Sidwell, Karagounis-Ruiz, Petric, Duff-Rodalega.
Manchester United (4-4-2): De Gea-Rafael, Ferdinand, Smalling, Evra-Cleverley, Carrick, Anderson, Valencia-Van Persie, Rooney.