Uruguay, who finished fourth in the 2010 edition, look a formidable side this time as well with its attack led by Edinson Cavani and Luis Suarez and of course Diego Forlan, the star of 2010.
FIFA RANKINGS: URUGUAY: 7, COSTA RICA: 34
Suarez, who plays for Liverpool, however is suffering from a knee injury but that shouldn't worry the Uruguayans in their first match much.
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Costa Rica, on the other hand, are considered more a spoiler in Group D which also features former champions England and Italy.
The Costa Ricans, who have a decent defence, will bank on their skipper and attacking midfielder Bryan Ruiz who has scored 12 goals since 2005. Twenty-one-year-old Joel Campbell and veteran Christian Bolanos are among other notable players in the Costa Rican side. The absence of defender Bryan Oviedo may make the team, which conceded just seven goals in 10 qualifying matches, may suffer.
Costa Rica's best performance in a World Cup came in 1990 when it made it to the Round of Sixteen.
The match will begin at 12.30 am IST.
Uruguay: Muslera, Lugano (c), Godin, Gargano, Rodriguez, Forlan, Stuani, Pereira, Arevalo, Cavani, Caceres. Coach: Oscar Tabarez
Costa Rica: Navas, Gonzalez, Umana, Borges, Duarte, Bolanos, Campbell, Ruiz (c), DÍaz, Gamboa, Tejeda. Coach: Jorge Luis Pinto