However, with one of the best goalkeepers in the world, a solid defense and a coach with a defensive mentality, we can be assured that Sevilla might find it hard to sneak in an away goal.
David De Gea has been in scintillating form for quite a while and one can expect the world class saves from point blank range if the defense falters.
With Manchester United poised to play defensively and Sevilla being an attacking team, one could expect repeat tactics from the match against Liverpool, long balls.
Both goals against Liverpool were created by a boot up the field reaching Romelu Lukaku. Sevilla's Gabriel Mercado, Clement Lenglet or Simon Kjaer can expect a tough night trying to contain the big Belgian.
Once the long balls are launched, it is highly important to win the second balls to create chances. Sevilla's full backs will have a task on their hands trying to prevent Marcus Rashford and Alexis Sanchez from winning second balls.
Given the two goals that Rashford scored this Saturday and with a spot in the England team for the World up for grabs, trying to bet on him scoring a goal or influencing the game wouldn't be foolish.
Scott McTominay and Nemajna Matic have been brilliant for United and they have helped soften the blow of Paul Pogba being unavailable for a while.
Pogba mostly wont feature as he only had a light training session a few days back.