Lieutenant-General Solomon Makgale said 27-year-old Meyiwa was gunned down and declared dead on admission to hospital late Sunday, reports Xinhua.
"We can confirm that goalkeeper Senzo Meyiwa has been shot and sadly declared dead on arrival at hospital," the South African Police Service (SAPS) said on its Twitter account.
"We must emphasize break of protocol...We know there are upset & hurt pple at the house where incident occurred and at hospital. Calm please." it added.
"No one present in the house was hurt... We can assure all South Africans that we will do all can to bring Meyiwa's killers book..." said SAPS