The Gunners have an impressive home record against non-English opposition in Europe, not losing in 45 games. But Arsene Wenger's side are hit with injuries to key players.
Alex Oxlade-Chamberlian is suffering from a hip injury while Theo Walcott is sidelined with a rib injury. Bacary Sagna, Laurent Koscielny, Abou Diaby are all sidelined.
Although Jack Wilshere played a full game with the Under 21s he is likely to feature on the bench while left-back Andre Santos will continue ahead of fit Kieran Gibbs.
Schalke face few injury troubles but coach Huub Stevens may play Julian Draxler, who suffered a broken wrist, with a cast on his arm if the player feels comfortable.
Arsenal have unbeaten home record while Schalke have failed to score in four out of fove matches against Premier League teams.
*Lukas Podolski has scored four goals in three Champions League matches.
*Schalke have scored three goals in three shots on target.
Arsenal (4-2-3-1): Mannone-Jenkinson, Mertesacker, Vermaelen, Santos-Arteta, Ramsey-Gervinho, Cazorla, Podolski-Giroud
Schalke (4-2-3-1): Unnerstall-Uchida, Howedes, Matip, Fuchs-Neustadter, Hoger-Farfan, Holtby, Afellay-Huntelaar