London, March 10: Tottenham and Valencia each face uphill battles ahead of Tuesday's Champions League last-16 second legs.
Spurs, rocked by injuries in attack, go to RB Leipzig trailing 1-0 from their home leg at the Tottenham Hotspur Stadium three weeks ago.
Valencia's hopes of progression are even more remote after a thumping 4-1 defeat at Atalanta. They will play the home second leg without the backing of supporters, too, due to the coronavirus outbreak.
We take a look at the key Opta statistics ahead of the two fixtures.
RB Leipzig v Tottenham
1 - Tottenham have only lost one of their five away Champions League games in Germany (W2 D2), although that defeat came earlier this season at Bayern Munich.
8 - Spurs have been eliminated in eight of their past 10 major European knockout ties when they have lost the first leg. But they overturned a deficit the previous time this happened against Ajax in last season's Champions League semi-finals.
4 - Four of Leipzig's past five Champions League goals have been penalties. Only Barcelona in 2011-12 (five) have ever scored more than four spot-kicks in a single campaign.
6 - Timo Werner is yet to find the net in six home Champions League appearances, attempting 22 shots without success. In away games, he has seven goals from 14 shots. Werner has scored more Champions League goals without netting at home than any other player in the competition's history.
7 - Jose Mourinho has lost more away Champions League games in Germany (seven) than in any other country.
Valencia v Atalanta
4 - Only four of the previous 36 teams to lose the first leg of a Champions League knockout tie by three or more goals have then progressed. However, two have been Spanish sides – Deportivo La Coruna in 2003-04 versus Milan and Barcelona in 2016-17 versus Paris Saint-Germain.
3 - In the first leg, Atalanta became only the third team to score four goals in their first ever Champions League knockout match, after Manchester United (4-0 versus Porto in 1996-97) and opponents Valencia (5-2 versus Lazio in 1999-00).
9 - Valencia are winless in nine Champions League knockout matches (D5 L4) and have not scored three goals in such a game since winning 3-0 against Leeds United in May 2001.
0 - The Serie A side are yet to have an Italian scorer in the Champions League this season. But their 12 goals have been scored by 10 different players of nine different nationalities. Only Arsenal in 2009-10, Manchester United in 2010-11 and Borussia Dortmund in 2016-17 have had 10 different nationalities net in one campaign.
6 - Atalanta scored with six of their first 29 shots on target in the Champions League this season but have since found the net with six of their previous eight, including their four most recent shots on target in their 4-1 win in the first leg.