Giants vs Brewers Prediction, MLB 25: The San Francisco Giants host the Milwaukee Brewers at Oracle Park on April 24, 2025, to wrap up their series. The Giants are currently listed as -146 moneyline favorites, while the Brewers are +122 underdogs.
San Francisco aims to lean on their powerful offensive core led by Wilmer Flores and Jung Hoo Lee, while the Brewers counter with solid contributions from Jackson Chourio and a pitching staff that's been sharp all season. Expect a tightly contested battle as both teams look to break out of their recent 5-5 stretch.

The Giants are 5-5 in their last 10 games, scoring an average of 4.8 runs per game. Despite a mid-tier 4.18 ERA, the pitching staff maintains a strong 9.3 K/9. Wilmer Flores continues to anchor the offense with seven home runs and 27 RBIs, while Jung Hoo Lee remains consistent with a team-high .333 batting average.
Milwaukee enters with a matching 5-5 record over their last 10 games, averaging 4.8 runs per contest. Their strength lies in a 2.79 ERA from their pitching staff. Offensively, Jackson Chourio and Brice Turang have delivered consistently, while Sal Frelick and Christian Yelich provide support throughout the lineup.
| Date | Favorite | Spread | Total | Favorite Moneyline | Underdog Moneyline | Result |
|---|---|---|---|---|---|---|
| Apr 23, 2025 | Giants | -1.5 | 6.5 | -146 | +122 | 4–2 Giants |
| Apr 22, 2025 | Giants | -1.5 | 6.5 | -140 | +119 | 3–11 Brewers |
| Apr 21, 2025 | Giants | -1.5 | 6.5 | -138 | +115 | 5–2 Giants |
| Sep 12, 2024 | Giants | -1.5 | 7.5 | -135 | +110 | 0–3 Brewers |
| Sep 11, 2024 | Giants | -1.5 | 8.0 | -130 | +105 | 13–2 Giants |
| Bet Type | Odds |
|---|---|
| Giants Moneyline | -146 |
| Brewers Moneyline | +122 |
| Run Line (Giants -1.5) | +158 |
| Over/Under (6.5 Runs) | Over -110 / Under -110 |
Both teams enter this contest in similar form, but the matchup leans slightly in favor of San Francisco. The Giants have been consistent at home, with Jung Hoo Lee and Wilmer Flores setting the tone offensively. Milwaukee counters with a more dominant pitching staff and explosive potential from Chourio and Turang.
Still, the Giants’ offensive versatility and familiarity with Oracle Park give them the edge in a close, low-scoring matchup. Expect San Francisco to narrowly escape with a win, but Milwaukee remains a live underdog.
Prediction: Giants 4, Brewers 3
Best Bet: Giants Moneyline (-146)
Value Pick: Over 6.5 Runs (-110)