MLB April 22-27: Full Schedule of Exciting Matchups, Key Games, Full Match Times ET (April 22-27, 2025)

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The MLB schedule from April 22nd to 27th offers a packed lineup of exciting matchups, featuring key games across both the American and National Leagues. From divisional showdowns to interleague play, baseball fans can look forward to thrilling action each day.

Whether it's a late-night game or an afternoon matchup, teams like the Yankees, Braves, and Dodgers are ready to battle it out for supremacy. Here's the schedule

Tuesday, April 22nd

• Yankees vs. Guardians - 6:10 PM ET
• Padres vs. Tigers - 6:40 PM ET
• Reds vs. Marlins - 6:40 PM ET
• Mariners vs. Red Sox - 6:45 PM ET
• Orioles vs. Nationals - 6:45 PM ET
• Phillies vs. Mets - 7:10 PM ET
• Cardinals vs. Braves - 7:15 PM ET
• Dodgers vs. Cubs - 7:40 PM ET
• Rockies vs. Royals - 7:40 PM ET
• White Sox vs. Twins - 7:40 PM ET
• Blue Jays vs. Astros - 8:10 PM ET
• Pirates vs. Angels - 9:38 PM ET
• Rays vs. Diamondbacks - 9:40 PM ET
• Brewers vs. Giants - 9:45 PM ET
• Rangers vs. Athletics - 10:05 PM ET

Wednesday, April 23rd

• Cardinals vs. Braves - 12:15 PM ET
• Yankees vs. Guardians - 1:10 PM ET
• Padres vs. Tigers - 1:10 PM ET
• Reds vs. Marlins - 1:10 PM ET
• Phillies vs. Mets - 1:10 PM ET
• Mariners vs. Red Sox - 6:45 PM ET
• Orioles vs. Nationals - 6:45 PM ET
• Dodgers vs. Cubs - 7:00 PM ET
• White Sox vs. Twins - 7:40 PM ET
• Rockies vs. Royals - 7:40 PM ET
• Blue Jays vs. Astros - 7:40 PM ET
• Pirates vs. Angels - 9:38 PM ET
• Rays vs. Diamondbacks - 9:40 PM ET
• Brewers vs. Giants - 9:45 PM ET
• Rangers vs. Athletics - 10:05 PM ET

Thursday, April 24th

• White Sox vs. Twins - 1:10 PM ET
• Mariners vs. Red Sox - 1:35 PM ET
• Rockies vs. Royals - 2:10 PM ET
• Brewers vs. Giants - 3:45 PM ET
• Orioles vs. Nationals - 6:45 PM ET
• Pirates vs. Angels - 9:29 PM ET
• Rays vs. Diamondbacks - 9:40 PM ET
• Rangers vs. Athletics - 10:05 PM ET

Friday, April 25th

• Phillies vs. Cubs - 2:20 PM E
• Orioles vs. Tigers - 6:40 PM ET
• Mets vs. Nationals - 6:45 PM ET
• Blue Jays vs. Yankees - 7:05 PM ET
• Red Sox vs. Guardians - 7:10 PM ET
• Astros vs. Royals - 7:40 PM ET
• Angels vs. Twins - 7:40 PM ET
• Brewers vs. Cardinals - 8:15 PM ET
• Reds vs. Rockies - 8:40 PM ET
• Braves vs. Diamondbacks - 9:40 PM ET
• Marlins vs. Mariners - 9:40 PM ET
• Rays vs. Padres - 9:40 PM ET
• White Sox vs. Athletics - 10:05 PM ET
• Pirates vs. Dodgers - 10:10 PM ET
• Rangers vs. Giants - 10:15 PM ET

Saturday, April 26th

• Blue Jays vs. Yankees - 1:05 PM ET
• Orioles vs. Tigers - 1:10 PM ET
• Angels vs. Twins - 2:10 PM ET
• Brewers vs. Cardinals - 2:15 PM ET
• Reds vs. Rockies - 3:10 PM ET
• Phillies vs. Cubs - 4:05 PM ET
• Mets vs. Nationals - 4:05 PM ET
• Rangers vs. Giants - 4:05 PM ET
• White Sox vs. Athletics - 4:05 PM ET
• Red Sox vs. Guardians - 6:10 PM ET
• Astros vs. Royals - 7:10 PM ET
• Braves vs. Diamondbacks - 8:10 PM ET
• Rays vs. Padres - 8:40 PM ET
• Pirates vs. Dodgers - 9:10 PM ET
• Marlins vs. Mariners - 9:40 PM ET

Read More: Yankees vs Guardians Live Stream, MLB 2025: Where to Watch Yankees vs Guardians Free Online, TV?

Sunday, April 27th

• Blue Jays vs. Yankees - 1:35 PM ET
• Mets vs. Nationals - 1:35 PM ET
• Red Sox vs. Guardians - 1:40 PM ET
• Orioles vs. Tigers - 1:40 PM ET
• Angels vs. Twins - 1:40 PM ET
• Astros vs. Royals - 2:10 PM ET
• Brewers vs. Cardinals - 2:15 PM ET
• Reds vs. Rockies - 3:10 PM ET
• White Sox vs. Athletics - 4:05 PM ET
• Rangers vs. Giants - 4:05 PM ET
• Rays vs. Padres - 4:10 PM ET
• Marlins vs. Mariners - 4:10 PM ET
• Pirates vs. Dodgers - 4:10 PM ET
• Braves vs. Diamondbacks - 4:10 PM ET
• Phillies vs. Cubs - 7:10 PM ET