| # | Player | Runs | Balls Faced | 4s | 6s | SR | Against | Venue | Date |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Faf du Plessis | 119 | 56 | 11 | 5 | 212.50 | West Indies | Johannesburg | 11-Jan-2015 |
| 2 | RE Levi | 117 | 51 | 5 | 13 | 229.41 | New Zealand | Hamilton | 19-Feb-2012 |
| 3 | Reeza Hendricks | 117 | 63 | 7 | 10 | 185.71 | Pakistan | Centurion | 13-Dec-2024 |
| 4 | MN van Wyk | 114 | 70 | 9 | 7 | 162.85 | West Indies | Durban | 14-Jan-2015 |
| 5 | Rilee Rossouw | 109 | 56 | 7 | 8 | 194.64 | Bangladesh | Sydney | 27-Oct-2022 |
| 6 | David Miller | 106 | 47 | 8 | 7 | 225.53 | India | Guwahati | 02-Oct-2022 |
| 7 | David Miller | 101 | 36 | 7 | 9 | 280.55 | Bangladesh | Potchefstroom | 29-Oct-2017 |
| 8 | Rilee Rossouw | 100 | 48 | 7 | 8 | 208.33 | India | Indore | 04-Oct-2022 |
| 9 | Quinton de Kock | 100 | 44 | 9 | 8 | 227.27 | West Indies | Centurion | 26-Mar-2023 |
| 10 | Hashim Amla | 97 | 62 | 8 | 4 | 156.45 | Australia | Cape Town | 09-Mar-2016 |
| 11 | JP Duminy | 96 | 54 | 10 | 4 | 177.77 | Zimbabwe | Kimberley | 10-Oct-2010 |
| 12 | Rilee Rossouw | 96 | 55 | 10 | 5 | 174.54 | England | Cardiff | 28-Jul-2022 |
| 13 | Rassie van der Dussen | 94 | 60 | 5 | 6 | 156.66 | England | Sharjah | 06-Nov-2021 |
| 14 | LE Bosman | 94 | 45 | 5 | 9 | 208.88 | England | Centurion | 15-Nov-2009 |
| 15 | Herschelle Gibbs | 90 | 55 | 14 | 2 | 163.63 | West Indies | Johannesburg | 11-Sep-2007 |
| 16 | Graeme Smith | 89 | 58 | 11 | 1 | 153.44 | Australia | Johannesburg | 24-Feb-2006 |
| 17 | JM Kemp | 89 | 56 | 6 | 6 | 158.92 | New Zealand | Durban | 19-Sep-2007 |
| 18 | Graeme Smith | 88 | 44 | 8 | 6 | 200.00 | England | Centurion | 15-Nov-2009 |
| 19 | Reeza Hendricks | 87 | 51 | 6 | 6 | 170.58 | West Indies | Kingston | 23-May-2024 |
| 20 | JP Duminy | 86 | 43 | 10 | 3 | 200.00 | New Zealand | Chattogram | 24-Mar-2014 |
| 21 | David Miller | 85 | 45 | 5 | 7 | 188.88 | Pakistan | Lahore | 14-Feb-2021 |
| 22 | Faf du Plessis | 85 | 65 | 10 | 3 | 130.76 | Sri Lanka | Hambantota | 06-Aug-2013 |
| 23 | Hashim Amla | 85 | 51 | 11 | 1 | 166.66 | Bangladesh | Potchefstroom | 29-Oct-2017 |
| 24 | Reeza Hendricks | 83 | 44 | 11 | 2 | 188.63 | West Indies | Johannesburg | 28-Mar-2023 |
| 25 | David Miller | 82 | 40 | 4 | 8 | 205.00 | Pakistan | Durban | 10-Dec-2024 |
| 26 | Heinrich Klaasen | 81 | 46 | 7 | 5 | 176.08 | India | Cuttack | 12-Jun-2022 |
| 27 | AB de Villiers | 79 | 34 | 5 | 6 | 232.35 | Scotland | The Oval | 07-Jun-2009 |
| 28 | Faf du Plessis | 79 | 61 | 8 | - | 129.50 | Bangladesh | Mirpur | 05-Jul-2015 |
| 29 | Quinton de Kock | 79 | 52 | 6 | 5 | 151.92 | India | Bengaluru | 22-Sep-2019 |
| 30 | Faf du Plessis | 79 | 41 | 5 | 5 | 192.68 | Australia | Johannesburg | 06-Mar-2016 |
| 31 | JP Duminy | 78 | 48 | 9 | 1 | 162.50 | Australia | Melbourne | 11-Jan-2009 |
| 32 | CA Ingram | 78 | 50 | 8 | 3 | 156.00 | India | Johannesburg | 30-Mar-2012 |
| 33 | Rilee Rossouw | 78 | 50 | 7 | 3 | 156.00 | Australia | Adelaide | 05-Nov-2014 |
| 34 | Faf du Plessis | 78 | 45 | 6 | 4 | 173.33 | Pakistan | Cape Town | 01-Feb-2019 |
| 35 | Dwaine Pretorius | 77 | 42 | 7 | 3 | 183.33 | Sri Lanka | Johannesburg | 24-Mar-2019 |
| 36 | Tristan Stubbs | 76 | 42 | 8 | 3 | 180.95 | West Indies | Tarouba | 23-Aug-2024 |
| 37 | RD Rickelton | 76 | 48 | 3 | 6 | 158.33 | Ireland | Abu Dhabi | 27-Sep-2024 |
| 38 | David Miller | 75 | 44 | 4 | 5 | 170.45 | Ireland | Belfast | 22-Jul-2021 |
| 39 | Rassie van der Dussen | 75 | 46 | 7 | 5 | 163.04 | India | Delhi | 09-Jun-2022 |
| 40 | Rassie van der Dussen | 74 | 32 | 5 | 5 | 231.25 | England | Cape Town | 01-Dec-2020 |
| 41 | Reeza Hendricks | 74 | 41 | 8 | 2 | 180.48 | Pakistan | Cape Town | 01-Feb-2019 |
| 42 | Reeza Hendricks | 74 | 53 | 10 | 1 | 139.62 | Ireland | Bristol | 03-Aug-2022 |
| 43 | Quinton de Kock | 74 | 40 | 7 | 5 | 185.00 | U.S.A. | North Sound | 19-Jun-2024 |
| 44 | Jacques Kallis | 73 | 54 | 3 | 3 | 135.18 | India | Gros Islet | 02-May-2010 |
| 45 | Quinton de Kock | 72 | 51 | 5 | 2 | 141.17 | West Indies | St George's | 29-Jun-2021 |
| 46 | Temba Bavuma | 72 | 51 | 6 | 2 | 141.17 | Ireland | Belfast | 24-Jul-2021 |
| 47 | Tristan Stubbs | 72 | 28 | 2 | 8 | 257.14 | England | Bristol | 27-Jul-2022 |
| 48 | Graeme Smith | 71 | 40 | 9 | 4 | 177.50 | Pakistan | Johannesburg | 02-Feb-2007 |
| 49 | AB de Villiers | 71 | 29 | 6 | 6 | 244.82 | England | Johannesburg | 21-Feb-2016 |
| 50 | Reeza Hendricks | 70 | 50 | 8 | 1 | 140.00 | India | Johannesburg | 18-Feb-2018 |
| 51 | Quinton de Kock | 70 | 47 | 5 | 4 | 148.93 | Australia | Gqeberha | 23-Feb-2020 |
| 52 | Aiden Markram | 70 | 48 | 3 | 4 | 145.83 | West Indies | St George's | 03-Jul-2021 |
| 53 | Reeza Hendricks | 70 | 50 | 9 | - | 140.00 | England | Southampton | 31-Jul-2022 |
| 54 | JP Duminy | 69 | 41 | 7 | 2 | 168.29 | Australia | Brisbane | 13-Jan-2009 |
| 55 | AB de Villiers | 69 | 28 | 9 | 3 | 246.42 | England | Chattogram | 29-Mar-2014 |
| 56 | Hashim Amla | 69 | 38 | 8 | 3 | 181.57 | England | Johannesburg | 21-Feb-2016 |
| 57 | Quinton de Kock | 69 | 48 | 3 | 4 | 143.75 | India | Guwahati | 02-Oct-2022 |
| 58 | Heinrich Klaasen | 69 | 30 | 3 | 7 | 230.00 | India | Centurion | 21-Feb-2018 |
| 59 | Reeza Hendricks | 69 | 48 | 7 | 1 | 143.75 | Ireland | Belfast | 24-Jul-2021 |
| 60 | JP Duminy | 68 | 34 | 1 | 7 | 200.00 | India | Dharamsala | 02-Oct-2015 |
| 61 | H Davids | 68 | 51 | 7 | 2 | 133.33 | New Zealand | Gqeberha | 26-Dec-2012 |
| 62 | Quinton de Kock | 68 | 43 | 6 | 4 | 158.13 | India | Indore | 04-Oct-2022 |
| 63 | Reeza Hendricks | 68 | 28 | 11 | 2 | 242.85 | West Indies | Centurion | 26-Mar-2023 |
| 64 | MN van Wyk | 67 | 39 | 5 | 5 | 171.79 | India | Durban | 09-Jan-2011 |
| 65 | JP Duminy | 67 | 53 | 6 | 3 | 126.41 | Australia | Cape Town | 13-Oct-2011 |
| 66 | Rassie van der Dussen | 66 | 38 | 3 | 5 | 173.68 | Pakistan | Centurion | 13-Dec-2024 |
| 67 | Reeza Hendricks | 66 | 52 | 8 | 2 | 126.92 | Sri Lanka | Johannesburg | 24-Mar-2019 |
| 68 | Heinrich Klaasen | 66 | 33 | 4 | 4 | 200.00 | England | Centurion | 16-Feb-2020 |
| 69 | AB de Villiers | 65 | 58 | 4 | 2 | 112.06 | England | Southampton | 21-Jun-2017 |
| 70 | David Miller | 65 | 29 | 4 | 5 | 224.13 | Pakistan | Johannesburg | 03-Feb-2019 |
| 71 | Faf du Plessis | 65 | 38 | 6 | 2 | 171.05 | India | Colombo (RPS) | 02-Oct-2012 |
| 72 | Reeza Hendricks | 65 | 46 | 9 | - | 141.30 | Sri Lanka | Centurion | 22-Mar-2019 |
| 73 | Quinton de Kock | 65 | 22 | 2 | 8 | 295.45 | England | Durban | 14-Feb-2020 |
| 74 | Quinton de Kock | 65 | 38 | 4 | 4 | 171.05 | England | Gros Islet | 21-Jun-2024 |
| 75 | Farhaan Behardien | 64 | 52 | 4 | 2 | 123.07 | England | Southampton | 21-Jun-2017 |