| # | Player | Runs | Minutes | Balls Faced | 4s | 6s | Against | Venue | Date |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Willem Mulder | 367 | 410 | 334 | 49 | 4 | Zimbabwe | Bulawayo | 06-Jul-2025 |
| 2 | Hashim Amla | 311 | 790 | 529 | 35 | - | England | The Oval | 19-Jul-2012 |
| 3 | AB de Villiers | 278 | 601 | 418 | 23 | 6 | Pakistan | Abu Dhabi | 20-Nov-2010 |
| 4 | Graeme Smith | 277 | 541 | 373 | 35 | - | England | Birmingham | 24-Jul-2003 |
| 5 | Daryll Cullinan | 275 | 658 | 490 | 27 | 2 | New Zealand | Auckland | 27-Feb-1999 |
| 6 | Gary Kirsten | 275 | 878 | 642 | 26 | - | England | Durban | 26-Dec-1999 |
| 7 | RG Pollock | 274 | 417 | 401 | 43 | - | Australia | Durban | 05-Feb-1970 |
| 8 | Graeme Smith | 259 | 574 | 370 | 34 | - | England | Lord's | 31-Jul-2003 |
| 9 | RD Rickelton | 259 | 607 | 343 | 29 | 3 | Pakistan | Cape Town | 03-Jan-2025 |
| 10 | Derrick McGlew | 255 | 534 | - | 19 | - | New Zealand | Wellington | 06-Mar-1953 |
| 11 | Hashim Amla | 253 | 675 | 473 | 22 | - | India | Nagpur | 06-Feb-2010 |
| 12 | Eric Rowan | 236 | 550 | - | 28 | - | England | Leeds | 26-Jul-1951 |
| 13 | Graeme Smith | 234 | 627 | 388 | 16 | - | Pakistan | Dubai (DICS) | 23-Oct-2013 |
| 14 | Graeme Smith | 232 | 406 | 277 | 33 | 1 | Bangladesh | Chattogram | 29-Feb-2008 |
| 15 | AD Nourse | 231 | 289 | - | 36 | - | Australia | Johannesburg | 24-Dec-1935 |
| 16 | Herschelle Gibbs | 228 | 383 | 240 | 29 | 6 | Pakistan | Cape Town | 02-Jan-2003 |
| 17 | Gavin Hamilton | 226 | 518 | 388 | 28 | 3 | Bangladesh | Chattogram | 29-Feb-2008 |
| 18 | Jacques Kallis | 224 | 434 | 325 | 31 | 1 | Sri Lanka | Cape Town | 03-Jan-2012 |
| 19 | Jacques Rudolph | 222 | 521 | 383 | 29 | 2 | Bangladesh | Chattogram | 24-Apr-2003 |
| 20 | Gary Kirsten | 220 | 442 | 286 | 33 | 1 | Zimbabwe | Harare | 07-Sep-2001 |
| 21 | AB de Villiers | 217 | 480 | 333 | 17 | 2 | India | Ahmedabad | 03-Apr-2008 |
| 22 | Herschelle Gibbs | 211 | 659 | 468 | 23 | 3 | New Zealand | Christchurch | 11-Mar-1999 |
| 23 | Gary Kirsten | 210 | 650 | 525 | 24 | 1 | England | Manchester | 02-Jul-1998 |
| 24 | RG Pollock | 209 | 350 | - | 30 | - | Australia | Cape Town | 31-Dec-1966 |
| 25 | AD Nourse | 208 | 555 | - | 25 | - | England | Nottingham | 07-Jun-1951 |
| 26 | Hashim Amla | 208 | 475 | 371 | 22 | - | West Indies | Centurion | 17-Dec-2014 |
| 27 | George Faulkner | 204 | 315 | 320 | 26 | - | Australia | Melbourne | 31-Dec-1910 |
| 28 | Jacques Kallis | 201 | 389 | 270 | 15 | 5 | India | Centurion | 16-Dec-2010 |
| 29 | Eddie Barlow | 201 | 392 | - | 27 | - | Australia | Adelaide | 24-Jan-1964 |
| 30 | Hashim Amla | 201 | 707 | 477 | 27 | - | England | Cape Town | 02-Jan-2016 |
| 31 | Graeme Smith | 200 | 338 | 287 | 25 | - | Bangladesh | East London | 18-Oct-2002 |
| 32 | Dean Elgar | 199 | 553 | 388 | 15 | 3 | Bangladesh | Potchefstroom | 28-Sep-2017 |
| 33 | Faf du Plessis | 199 | 412 | 276 | 24 | - | Sri Lanka | Centurion | 26-Dec-2020 |
| 34 | Herschelle Gibbs | 196 | 442 | 354 | 25 | 1 | India | Gqeberha | 16-Nov-2001 |
| 35 | Hashim Amla | 196 | 350 | 221 | 21 | - | Australia | W.A.C.A | 30-Nov-2012 |
| 36 | Herschelle Gibbs | 192 | 474 | 335 | 24 | 3 | West Indies | Centurion | 16-Jan-2004 |
| 37 | Younis Khan | 189 | 420 | - | - | - | England | The Oval | 16-Aug-1947 |
| 38 | Jacques Kallis | 189 | 581 | 443 | 19 | 3 | Zimbabwe | Bulawayo | 14-Sep-2001 |
| 39 | Alan Melville | 189 | 364 | - | 16 | 1 | England | Nottingham | 07-Jun-1947 |
| 40 | Jacques Kallis | 186 | 383 | 262 | 25 | 3 | New Zealand | Johannesburg | 08-Nov-2007 |
| 41 | Dean Elgar | 185 | 425 | 287 | 28 | - | India | Centurion | 26-Dec-2023 |
| 42 | Herschelle Gibbs | 183 | 324 | 258 | 35 | 1 | England | The Oval | 04-Sep-2003 |
| 43 | Graeme Smith | 183 | 391 | 273 | 25 | - | England | Cape Town | 03-Jan-2010 |
| 44 | Jacques Kallis | 182 | 434 | 326 | 23 | 1 | England | The Oval | 19-Jul-2012 |
| 45 | Denis Lindsay | 182 | 273 | 227 | 25 | 5 | Australia | Johannesburg | 23-Dec-1966 |
| 46 | Alviro Petersen | 182 | 533 | 365 | 23 | - | England | Leeds | 02-Aug-2012 |
| 47 | Gary Kirsten | 180 | 558 | 461 | 20 | - | Sri Lanka | Durban | 26-Dec-2000 |
| 48 | Herschelle Gibbs | 179 | 305 | 236 | 29 | 1 | England | Birmingham | 24-Jul-2003 |
| 49 | AB de Villiers | 178 | 551 | 352 | 15 | 1 | West Indies | Bridgetown | 21-Apr-2005 |
| 50 | HH Dippenaar | 177 | 514 | 369 | 25 | 2 | Bangladesh | Chattogram | 24-Apr-2003 |
| 51 | Jacques Kallis | 177 | 479 | 344 | 20 | - | West Indies | Durban | 26-Dec-2003 |
| 52 | T de Zorzi | 177 | 432 | 269 | 12 | 4 | Bangladesh | Chattogram | 29-Oct-2024 |
| 53 | Hashim Amla | 176 | 511 | 378 | 24 | - | New Zealand | Johannesburg | 08-Nov-2007 |
| 54 | Herbert Taylor | 176 | 310 | - | 25 | - | England | Johannesburg | 23-Dec-1922 |
| 55 | RG Pollock | 175 | 283 | - | 18 | 3 | Australia | Adelaide | 24-Jan-1964 |
| 56 | Lance Klusener | 174 | 333 | 221 | 25 | 2 | England | Gqeberha | 09-Dec-1999 |
| 57 | AB de Villiers | 174 | 517 | 381 | 19 | - | England | Leeds | 18-Jul-2008 |
| 58 | Jacques Kallis | 173 | 419 | 351 | 15 | 2 | India | Nagpur | 06-Feb-2010 |
| 59 | Temba Bavuma | 172 | 376 | 280 | 20 | - | West Indies | Johannesburg | 08-Mar-2023 |
| 60 | AB de Villiers | 169 | 225 | 184 | 21 | 3 | Australia | W.A.C.A | 30-Nov-2012 |
| 61 | Daryll Cullinan | 168 | 425 | 306 | 20 | - | West Indies | Cape Town | 02-Jan-1999 |
| 62 | JP Duminy | 166 | 448 | 340 | 18 | - | Australia | Melbourne | 26-Dec-2008 |
| 63 | Younis Khan | 164 | 330 | - | - | - | England | Lord's | 29-Jun-1935 |
| 64 | AB de Villiers | 164 | 374 | 274 | 17 | 1 | Pakistan | Dubai (DICS) | 23-Oct-2013 |
| 65 | Andrew Hudson | 163 | 519 | 384 | 20 | - | West Indies | Bridgetown | 18-Apr-1992 |
| 66 | AJ Hall | 163 | 588 | 454 | 17 | - | India | Kanpur | 20-Nov-2004 |
| 67 | AB de Villiers | 163 | 313 | 196 | 12 | 7 | Australia | Cape Town | 19-Mar-2009 |
| 68 | William Endean | 162 | 452 | - | 9 | - | Australia | Melbourne | 24-Dec-1952 |
| 69 | Ashwell Prince | 162 | 333 | 223 | 23 | 2 | Bangladesh | Centurion | 26-Nov-2008 |
| 70 | Jacques Kallis | 162 | 364 | 264 | 21 | 1 | England | Durban | 26-Dec-2004 |
| 71 | Herschelle Gibbs | 161 | 484 | 307 | 25 | - | England | Johannesburg | 13-Jan-2005 |
| 72 | Jacques Kallis | 161 | 459 | 291 | 19 | - | India | Cape Town | 02-Jan-2011 |
| 73 | AB de Villiers | 160 | 303 | 205 | 19 | 2 | Sri Lanka | Cape Town | 03-Jan-2012 |
| 74 | Jacques Kallis | 160 | 345 | 289 | 26 | - | New Zealand | Bloemfontein | 17-Nov-2000 |
| 75 | Gary Kirsten | 160 | 372 | 227 | 17 | 1 | Bangladesh | Potchefstroom | 25-Oct-2002 |