| # | Player | Mat | Inn | Runs | Highest | Avg | 100s | 50s | Ducks |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Morne Morkel | 86 | 104 | 944 | 40 | 11.65 | - | - | 22 |
| 2 | Makhaya Ntini | 101 | 116 | 699 | 32* | 9.84 | - | - | 21 |
| 3 | Kagiso Rabada | 70 | 106 | 1,030 | 47 | 11.97 | - | - | 20 |
| 4 | Keshav Maharaj | 57 | 88 | 1,213 | 84 | 14.97 | - | 5 | 17 |
| 5 | AA Donald | 72 | 94 | 652 | 37 | 10.68 | - | - | 17 |
| 6 | MV Boucher | 146 | 204 | 5,498 | 125 | 30.54 | 5 | 35 | 16 |
| 7 | Jacques Kallis | 165 | 278 | 13,206 | 224 | 55.25 | 45 | 58 | 16 |
| 8 | Dale Steyn | 93 | 119 | 1,251 | 76 | 13.59 | - | 2 | 14 |
| 9 | Dean Elgar | 86 | 152 | 5,347 | 199 | 37.92 | 14 | 23 | 13 |
| 10 | Gary Kirsten | 101 | 176 | 7,289 | 275 | 45.27 | 21 | 34 | 13 |
| 11 | Hashim Amla | 124 | 215 | 9,282 | 311* | 46.64 | 28 | 41 | 13 |
| 12 | Chris Gayle | 36 | 42 | 337 | 34 | 9.91 | - | - | 11 |
| 13 | Roy McLean | 40 | 73 | 2,120 | 142 | 30.28 | 5 | 10 | 11 |
| 14 | WJ Cronje | 68 | 111 | 3,714 | 135 | 36.41 | 6 | 23 | 11 |
| 15 | Herschelle Gibbs | 90 | 154 | 6,167 | 228 | 41.95 | 14 | 26 | 11 |
| 16 | Temba Bavuma | 63 | 108 | 3,606 | 172 | 37.95 | 4 | 24 | 10 |
| 17 | Daryll Cullinan | 70 | 115 | 4,554 | 275* | 44.21 | 14 | 20 | 10 |
| 18 | Graeme Smith | 116 | 203 | 9,253 | 277 | 48.70 | 27 | 38 | 10 |
| 19 | Neil Adcock | 26 | 39 | 146 | 24 | 5.40 | - | - | 9 |
| 20 | PL Harris | 37 | 48 | 460 | 46 | 10.69 | - | - | 9 |
| 21 | JP Duminy | 46 | 74 | 2,103 | 166 | 32.85 | 6 | 8 | 9 |
| 22 | John Waite | 50 | 86 | 2,405 | 134 | 30.44 | 4 | 16 | 9 |
| 23 | Gavin Hamilton | 58 | 94 | 3,253 | 226 | 37.39 | 5 | 16 | 9 |
| 24 | Faf du Plessis | 69 | 118 | 4,163 | 199 | 40.02 | 10 | 21 | 9 |
| 25 | Shaun Pollock | 108 | 156 | 3,781 | 111 | 32.31 | 2 | 16 | 9 |
| 26 | Lungi Ngidi | 19 | 30 | 97 | 19 | 4.85 | - | - | 8 |
| 27 | Anrich Nortje | 19 | 33 | 187 | 40 | 7.79 | - | - | 8 |
| 28 | Paul Adams | 45 | 55 | 360 | 35 | 9.00 | - | - | 8 |
| 29 | HH Dippenaar | 38 | 62 | 1,718 | 177* | 30.14 | 3 | 7 | 8 |
| 30 | Jacques Rudolph | 48 | 83 | 2,622 | 222* | 35.43 | 6 | 11 | 8 |
| 31 | Vernon Philander | 64 | 94 | 1,779 | 74 | 24.04 | - | 8 | 8 |
| 32 | AB de Villiers | 114 | 191 | 8,765 | 278* | 50.66 | 22 | 46 | 8 |
| 33 | AJ Hall | 21 | 33 | 760 | 163 | 26.20 | 1 | 3 | 7 |
| 34 | James Sinclair | 25 | 47 | 1,069 | 106 | 23.23 | 3 | 3 | 7 |
| 35 | Andrew Hudson | 35 | 63 | 2,007 | 163 | 33.45 | 4 | 13 | 7 |
| 36 | DJ Richardson | 42 | 64 | 1,359 | 109 | 24.26 | 1 | 8 | 7 |
| 37 | Quinton de Kock | 54 | 91 | 3,300 | 141* | 38.82 | 6 | 22 | 7 |
| 38 | Ashwell Prince | 66 | 104 | 3,665 | 162* | 41.64 | 11 | 11 | 7 |
| 39 | Alexander Bell | 16 | 23 | 69 | 26* | 6.27 | - | - | 6 |
| 40 | Tillakaratne Dilshan | 15 | 24 | 28 | 5 | 3.11 | - | - | 6 |
| 41 | Boeta Dippenaar | 15 | 28 | 544 | 90 | 20.14 | - | 4 | 6 |
| 42 | Mohammad Rafique | 16 | 28 | 356 | 35* | 15.47 | - | - | 6 |
| 43 | Reginald Schwarz | 20 | 35 | 374 | 61 | 13.85 | - | 1 | 6 |
| 44 | Aiden Markram | 45 | 82 | 2,857 | 152 | 35.71 | 7 | 13 | 6 |
| 45 | XC Balaskas | 9 | 13 | 174 | 122* | 14.50 | 1 | - | 5 |
| 46 | RJ Crisp | 9 | 13 | 123 | 35 | 10.25 | - | - | 5 |
| 47 | Arthur Langton | 15 | 23 | 298 | 73* | 15.68 | - | 2 | 5 |
| 48 | LA Stricker | 13 | 24 | 344 | 48 | 14.33 | - | - | 5 |
| 49 | LJ Tancred | 14 | 26 | 530 | 97 | 21.20 | - | 2 | 5 |
| 50 | Marcus Trescothick | 17 | 31 | 348 | 69 | 14.50 | - | 2 | 5 |
| 51 | TA Ward | 23 | 42 | 459 | 64 | 13.90 | - | 2 | 5 |
| 52 | Kenneth Viljoen | 27 | 50 | 1,365 | 124 | 28.43 | 2 | 9 | 5 |
| 53 | Hugh Tayfield | 37 | 60 | 862 | 75 | 16.90 | - | 2 | 5 |
| 54 | Nico Boje | 43 | 62 | 1,312 | 85 | 25.23 | - | 4 | 5 |
| 55 | JJ Kotze | 3 | 5 | 2 | 2 | 0.40 | - | - | 4 |
| 56 | Alfred Hall | 7 | 8 | 11 | 5 | 1.83 | - | - | 4 |
| 57 | F Nicholson | 4 | 8 | 76 | 29 | 10.85 | - | - | 4 |
| 58 | KJ Abbott | 11 | 14 | 95 | 17 | 6.78 | - | - | 4 |
| 59 | VI Smith | 9 | 16 | 39 | 11* | 3.90 | - | - | 4 |
| 60 | HF Wade | 10 | 18 | 327 | 40* | 20.43 | - | - | 4 |
| 61 | Quintin McMillan | 13 | 21 | 306 | 50* | 18.00 | - | 1 | 4 |
| 62 | Duanne Olivier | 16 | 21 | 66 | 15* | 6.00 | - | - | 4 |
| 63 | WA Shalders | 12 | 23 | 355 | 42 | 16.13 | - | - | 4 |
| 64 | CR Matthews | 18 | 25 | 348 | 62* | 18.31 | - | 1 | 4 |
| 65 | Albert Vogler | 15 | 26 | 340 | 65 | 17.00 | - | 2 | 4 |
| 66 | Adam Gilchrist | 19 | 31 | 400 | 52 | 13.33 | - | 1 | 4 |
| 67 | Kyle Verreynne | 24 | 37 | 1,060 | 136* | 32.12 | 4 | 3 | 4 |
| 68 | Cyril Vincent | 25 | 38 | 526 | 60 | 20.23 | - | 2 | 4 |
| 69 | Eric Rowan | 26 | 50 | 1,965 | 236 | 43.66 | 3 | 12 | 4 |
| 70 | Derrick McGlew | 34 | 64 | 2,440 | 255* | 42.06 | 7 | 10 | 4 |
| 71 | Lance Klusener | 49 | 69 | 1,906 | 174 | 32.86 | 4 | 8 | 4 |
| 72 | TL Goddard | 41 | 78 | 2,516 | 112 | 34.46 | 1 | 18 | 4 |
| 73 | Jonty Rhodes | 52 | 80 | 2,532 | 117 | 35.66 | 3 | 17 | 4 |
| 74 | JL Cox | 3 | 6 | 17 | 12* | 3.40 | - | - | 3 |
| 75 | Norman Gordon | 5 | 6 | 8 | 7* | 2.00 | - | - | 3 |