Real vs Espanyol
Real Madrid will be aiming for a third successive La Liga win when they travel to struggling Espanyol later on Sunday.
Blancos forward Karim Benzema is set to return to the pitch with a protective cast over a broken finger, while Periquitos stars Mario Hermoso, Esteban Granero and Diego Lopez all face their former club.
Community derby
Saturday sees another derby match-up, as Valencia host local rivals Villarreal in what is often called the Derbi de la Comunitat (The Community Derby).
Always motivated for the trip to the regional capital, the Yellow Submarine have won on each of their last three LaLiga visits to Mestalla. Meanwhile Los Che coach Marcelino Garcia Toral will want to get one over his former club.
Shaky start
The weekend starts with fourth-placed Sevilla looking to recover from some shaky form with a home game at the Sanchez-Pizjuan against a Levante team who picked up their first league win of 2019 last weekend.
Two teams just above the relegation places meet elsewhere in Madrid on Saturday, with Leganes in 15th hoping their strong form in front of their own fans at Butarque will continue and Eibar aiming for an upturn in fortunes having taken just two points from 15 on the road.
Unbeaten run
Elsewhere in the Basque Country, Real Sociedad will aim to continue their unbeaten run to 2019 in La Liga, while bottom club Huesca know that each game is already close to 'must-win' given their position in the table.
The weekend's action ends on Monday with fifth-placed Alaves aiming to maintain their unbeaten 2018-19 record at Mendizorrotza, but visitors Rayo Vallecano have taken 10 points from their last 12 as they start climbing up the rankings.